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In reproduction studies with SINEMETno effects on fertility were found in rats receiving doses of approximately two times the maximum daily human dose of carbidopa and four times the maximum daily human dose of levodopa.
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Because both therapeutic and adverse responses occur more rapidly with SINEMET than with levodopa alonepatients should be monitored closely during the dose adjustment periodSpecificallyinvoluntary movements will occur more rapidly with SINEMET than with levodopaThe occurrence of involuntary movements may require dosage reductionBlepharospasm may be a useful early sign of excess dosage in some patients.
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